Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


RGD ID: 70995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Metap2
Name: methionyl aminopeptidase 2
Acc ID: CHEBI:48635
Term: fumagillin
Definition: A meroterpenoid resulting from the formal condensation of the hydroxy group of fumagillol with the carboxylic acid group of (all-E)-deca-2,4,6,8-tetraenedioic acid. Originally isolated from the fungus Aspergillus fumigatus, it is used for the control of Nosema infection in honey bees.
Chemical ID: MESH:C026211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Metap2multiple interactionsEXP 6480464CTDfumagillin promotes the reaction [Diethylnitrosamine results in increased expression of METAP2 mRNA]

Metap2decreases activityISORGD:7321036480464CTDfumagillin results in decreased activity of METAP2 protein

PMID:14534293, PMID:15516829
Metap2multiple interactionsISORGD:7321036480464CTD[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein

Go Back to source page   Continue to Ontology report


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.