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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Metap2
Name: methionyl aminopeptidase 2
Acc ID: CHEBI:48635
Term: fumagillin
Definition: A meroterpenoid resulting from the formal condensation of the hydroxy group of fumagillol with the carboxylic acid group of (all-E)-deca-2,4,6,8-tetraenedioic acid. Originally isolated from the fungus Aspergillus fumigatus, it is used for the control of Nosema infection in honey bees.
Chemical ID: MESH:C026211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Metap2multiple interactionsEXP 6480464CTDfumagillin promotes the reaction [Diethylnitrosamine results in increased expression of METAP2 mRNA]

PMID:15682466
Metap2decreases activityISORGD:7321036480464CTDfumagillin results in decreased activity of METAP2 protein

PMID:14534293, PMID:15516829
Metap2multiple interactionsISORGD:7321036480464CTD[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein

PMID:14534293
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.