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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2520
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:48538
Term: apomorphine
Definition: An isoquinoline alkaloid that has formula C17H17NO2.
Chemical ID: MESH:D001058
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd2affects response to substanceEXP 6480464CTDDRD2 protein affects the susceptibility to ApomorphinePMID:14639100 PMID:2571179 PMID:8103596
Drd2multiple interactionsEXP 6480464CTDRisperidone inhibits the reaction [Apomorphine binds to and results in increased activity of DRD2 protein]PMID:7520908
Drd2increases response to substanceISODrd2 (Mus musculus)6480464CTDDRD2 protein results in increased susceptibility to ApomorphinePMID:19497322
Drd2multiple interactionsISODrd2 (Mus musculus)6480464CTD[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]PMID:8103921
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