GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Xdh | multiple interactions | EXP | | 6480464 | CTD | [Xanthine co-treated with XDH protein] results in increased expression of SOD2 protein | PMID:22718889 | Xdh | multiple interactions | ISO | XDH (Homo sapiens) | 6480464 | CTD | [[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; [Xanthine co-treated with XDH protein] results in decreased activity of KCNH2 protein; [Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein] | PMID:12531891 PMID:14973143 PMID:19268487 | Xdh | multiple interactions | ISO | Xdh (Rattus norvegicus) | 6480464 | CTD | 3,4-dihydroxyphenylethanol inhibits the reaction [[Xanthine co-treated with XDH protein] results in decreased phosphorylation of HSPB2 protein]; 3,4-dihydroxyphenylethanol inhibits the reaction [[Xanthine co-treated with XDH protein] results in increased cleavage of CASP3 protein]; 3,4-dihydroxyphenylethanol inhibits the reaction [[Xanthine co-treated with XDH protein] results in increased phosphorylation of MAPKAPK2 protein]; 3,4-dihydroxyphenylethanol promotes the reaction [[Xanthine co-treated with XDH protein] results in decreased phosphorylation of JUN protein]; [2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased activity of XDH protein] which results in decreased abundance of Xanthine; [Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of AK2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DES protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DLAT protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ETFB protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of FABP3 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HADH protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSP90AB1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPA9 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPB6 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PKM protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PPP2R1A protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PRDX6 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of SOD2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of C1QBP protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of CYCS protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of VDAC1 protein; [Xanthine co-treated with XDH protein] affects the expression of MYL2 protein; [Xanthine co-treated with XDH protein] affects the localization of HSF1 protein; [Xanthine co-treated with XDH protein] inhibits the reaction [carbobenzoxy-leucyl-leucyl-leucine results in increased expression of HIF1A protein]; [Xanthine co-treated with XDH protein] inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; [Xanthine co-treated with XDH protein] inhibits the reaction [Nitroprusside results in increased abundance of Cyclic GMP]; [Xanthine co-treated with XDH protein] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Xanthine co-treated with XDH protein] promotes the reaction [myricetin results in decreased activity of TXNRD1 protein modified form]; [Xanthine co-treated with XDH protein] results in decreased expression of ACAT1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of ACO2 protein; [Xanthine co-treated with XDH protein] results in decreased expression of ATP5F1A protein; [Xanthine co-treated with XDH protein] results in decreased expression of CKM protein; [Xanthine co-treated with XDH protein] results in decreased expression of CRYAB protein; [Xanthine co-treated with XDH protein] results in decreased expression of DES protein; [Xanthine co-treated with XDH protein] results in decreased expression of ECH1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of ECHS1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of ENO1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of FABP3 protein; [Xanthine co-treated with XDH protein] results in decreased expression of GUCY1A1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of GUCY1B1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of HADH protein; [Xanthine co-treated with XDH protein] results in decreased expression of HSP90AB1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of HSPA8 protein; [Xanthine co-treated with XDH protein] results in decreased expression of HSPB6 protein; [Xanthine co-treated with XDH protein] results in decreased expression of HSPD1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of IDH2 protein; [Xanthine co-treated with XDH protein] results in decreased expression of LDHB protein; [Xanthine co-treated with XDH protein] results in decreased expression of MDH1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of MDH2 protein; [Xanthine co-treated with XDH protein] results in decreased expression of OXCT1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of PKM protein; [Xanthine co-treated with XDH protein] results in decreased expression of SUCLG2 protein; [Xanthine co-treated with XDH protein] results in decreased phosphorylation of HSPB2 protein; [Xanthine co-treated with XDH protein] results in decreased phosphorylation of JUN protein; [Xanthine co-treated with XDH protein] results in increased abundance of Glutathione; [Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]; [Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein; [Xanthine co-treated with XDH protein] results in increased cleavage of CASP3 protein; [Xanthine co-treated with XDH protein] results in increased expression of CYCS protein; [Xanthine co-treated with XDH protein] results in increased expression of FH protein; [Xanthine co-treated with XDH protein] results in increased expression of HMOX1 mRNA; [Xanthine co-treated with XDH protein] results in increased expression of HPSE mRNA; [Xanthine co-treated with XDH protein] results in increased expression of HPSE protein; [Xanthine co-treated with XDH protein] results in increased expression of MYL3 protein; [Xanthine co-treated with XDH protein] results in increased expression of SOD2 mRNA; [Xanthine co-treated with XDH protein] results in increased expression of TNNT2 protein; [Xanthine co-treated with XDH protein] results in increased phosphorylation of MAPKAPK2 protein; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein]; Quercetin inhibits the reaction [[Xanthine co-treated with XDH protein] results in increased cleavage of CASP3 protein]; Quercetin inhibits the reaction [[Xanthine co-treated with XDH protein] results in increased phosphorylation of MAPKAPK2 protein] | PMID:12595275 PMID:16618767 PMID:17339839 PMID:19135123 PMID:19429930 PMID:19464573 PMID:21920950 PMID:26374991 PMID:7743507 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |