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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303246
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dek
Name: DEK proto-oncogene
Acc ID: CHEBI:48430
Term: 4-methyl-2-oxopentanoic acid
Definition: A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Chemical ID: MESH:C013082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13490756480464CTDDEK protein results in decreased chemical synthesis of and results in decreased secretion of alpha-ketoisocaproic acid

PMID:28558019
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.