GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ESR1 | decreases expression | EXP | | 6480464 | CTD | triclocarban results in decreased expression of ESR1 mRNA; triclocarban results in decreased expression of ESR1 protein | PMID:24740835 | ESR1 | multiple interactions | EXP | | 6480464 | CTD | ESR1 mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA]; ESR1 protein affects the reaction [triclocarban results in increased expression of CYP1B1 mRNA]; ESR1 protein affects the reaction [triclocarban results in increased expression of CYP2B6 mRNA]; triclocarban analog promotes the reaction [Estradiol results in increased activity of ESR1 protein]; triclocarban promotes the reaction [Estradiol results in increased activity of ESR1 protein] | PMID:18795164 PMID:22761658 PMID:23524099 | |
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