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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:48347
Term: triclocarban
Definition: A member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.
Chemical ID: MESH:C009540
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3multiple interactionsISORGD:13441636480464CTDNR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A1 mRNA] NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A3 mRNA] NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A4 mRNA] NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A6 mRNA] NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A9 mRNA]

PMID:22761658
Nr1i3multiple interactionsISORGD:15526296480464CTDNR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of CYP2B10 mRNA] NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of CYP2B10 protein]

PMID:22761658
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