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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:48347
Term: triclocarban
Definition: A member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.
Chemical ID: MESH:C009540
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionISORGD:7365596480464CTDtriclocarban results in decreased expression of ESR1 mRNA triclocarban results in decreased expression of ESR1 protein

PMID:24740835
Esr1multiple interactionsISORGD:7365596480464CTDESR1 mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA] ESR1 protein affects the reaction [triclocarban results in increased expression of CYP1B1 mRNA] ESR1 protein affects the reaction [triclocarban results in increased expression of CYP2B6 mRNA] triclocarban analog promotes the reaction [Estradiol results in increased activity of ESR1 protein] triclocarban promotes the reaction [Estradiol results in increased activity of ESR1 protein]

PMID:18795164 PMID:22761658 PMID:23524099
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