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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:48347
Term: triclocarban
Definition: A member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.
Chemical ID: MESH:C009540
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionEXP 6480464CTDtriclocarban results in increased expression of CYP1A1 mRNA

PMID:31576746
Cyp1a1multiple interactionsISORGD:7308706480464CTD[bisphenol A co-treated with triclocarban] results in increased expression of CYP1A1 mRNA [butylparaben co-treated with triclocarban] results in increased expression of CYP1A1 mRNA [Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA [Genistein co-treated with triclocarban] results in increased expression of CYP1A1 mRNA AHR mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA] ESR1 mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA] triclocarban inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] triclocarban inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]

PMID:23524099
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