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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1583689
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a5
Name: UDP glucuronosyltransferase family 1 member A5
Acc ID: CHEBI:48347
Term: triclocarban
Definition: A member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.
Chemical ID: MESH:C009540
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a5increases expressionISORGD:13435196480464CTDtriclocarban results in increased expression of UGT1A4 mRNA

PMID:22761658
Ugt1a5multiple interactionsISORGD:13435196480464CTDNR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A4 mRNA]

PMID:22761658
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