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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:48282
Term: 5-methoxy-N,N-diisopropyltryptamine
Definition: A tryptamine that has formula C17H26N2O.
Chemical ID: MESH:C033696
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2d4decreases activityISORGD:7362176480464CTD5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 proteinPMID:26599973
Cyp2d4multiple interactionsISORGD:7362176480464CTD[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of DextromethorphanPMID:26599973
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