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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313391
Species: Homo sapiens
RGD Object: Gene
Symbol: IDH2
Name: isocitrate dehydrogenase (NADP(+)) 2
Acc ID: CHEBI:48153
Term: D-erythrose 4-phosphate
Definition: An erythrose phosphate that is D-erythrose carrying a phosphate group at position 4. It is an intermediate in the pentose phosphate pathway and Calvin cycle.
Chemical ID: MESH:C026959
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IDH2increases abundanceISOIdh2 (Mus musculus)6480464CTDIDH2 protein mutant form results in increased abundance of erythrose 4-phosphatePMID:27469509
IDH2multiple interactionsISOIdh2 (Mus musculus)6480464CTDTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of erythrose 4-phosphate]PMID:27469509
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