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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732503
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:48080
Term: brefeldin A
Definition: A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.
Chemical ID: MESH:D020126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases phosphorylationISOMapk1 (Rattus norvegicus)6480464CTDBrefeldin A results in decreased phosphorylation of MAPK1 proteinPMID:24090963
Mapk1multiple interactionsISOMapk1 (Rattus norvegicus)6480464CTDBrefeldin A inhibits the reaction [Levodopa results in increased phosphorylation of MAPK1 protein]PMID:25044243
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