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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:48080
Term: brefeldin A
Definition: A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.
Chemical ID: MESH:D020126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDBrefeldin A results in increased expression of DDIT3 protein

PMID:20493918
multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein], Apigenin inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein], Glutathione inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]

PMID:20493918
increases expressionISORGD:691656480464CTDBrefeldin A results in increased expression of DDIT3 mRNA, Brefeldin A results in increased expression of DDIT3 protein

PMID:19428936, PMID:20626587, PMID:24865413, PMID:27358234
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.