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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303073
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xbp1
Name: X-box binding protein 1
Acc ID: CHEBI:48080
Term: brefeldin A
Definition: A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.
Chemical ID: MESH:D020126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xbp1increases activityISOXBP1 (Homo sapiens)6480464CTDBrefeldin A results in increased activity of XBP1 proteinPMID:18723477
Xbp1increases expressionISOXBP1 (Homo sapiens)6480464CTDBrefeldin A results in increased expression of XBP1 proteinPMID:27358234
Xbp1multiple interactionsISOXBP1 (Homo sapiens)6480464CTDbortezomib inhibits the reaction [Brefeldin A results in increased activity of XBP1 protein]PMID:18723477
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