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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734104
Species: Mus musculus
RGD Object: Gene
Symbol: Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1h4multiple interactionsEXP 6480464CTDNR1H4 protein affects the reaction [epigallocatechin gallate results in increased expression of FGF15 mRNA]; NR1H4 protein affects the reaction [epigallocatechin gallate results in increased expression of NR0B2 mRNA]PMID:22178739
Nr1h4increases activityISONR1H4 (Homo sapiens)6480464CTDepigallocatechin gallate results in increased activity of NR1H4 proteinPMID:22178739
Nr1h4multiple interactionsISONR1H4 (Homo sapiens)6480464CTD[epigallocatechin gallate co-treated with gallocatechol] results in increased activity of NR1H4 protein; epigallocatechin gallate inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; epigallocatechin gallate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of NR1H4 mRNA]; epigallocatechin gallate inhibits the reaction [GW 4064 results in increased activity of NR1H4 protein]; epigallocatechin gallate inhibits the reaction [GW 4064 results in increased expression of NR1H4 mRNA]PMID:22178739
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