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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731072
Species: Homo sapiens
RGD Object: Gene
Symbol: VEGFA
Name: vascular endothelial growth factor A
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VEGFAdecreases expressionEXP 6480464CTDepigallocatechin gallate results in decreased expression of VEGFA mRNAPMID:20346928 PMID:32512070
VEGFAdecreases secretionEXP 6480464CTDepigallocatechin gallate results in decreased secretion of VEGFA proteinPMID:17992120
VEGFAmultiple interactionsEXP 6480464CTD[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of VEGFA mRNA; epigallocatechin gallate inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA mRNA]]; epigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased expression of VEGFA protein]]PMID:22079256 PMID:26800359 PMID:36162953
VEGFAmultiple interactionsISOVegfa (Mus musculus)6480464CTDepigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of VEGFA protein]PMID:22101032
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