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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730821
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP2multiple interactionsEXP 6480464CTDepigallocatechin gallate inhibits the reaction [Particulate Matter results in increased expression of MMP2 protein]PMID:31252129
MMP2multiple interactionsISOMmp2 (Rattus norvegicus)6480464CTDepigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]; epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of MMP2 mRNA]; epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of MMP2 protein]PMID:17481882
MMP2multiple interactionsISOMmp2 (Mus musculus)6480464CTDepigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of MMP2 mRNA]PMID:20438794
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