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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69147
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP9
Name: caspase 9
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP9affects activityEXP 6480464CTDepigallocatechin gallate affects the activity of CASP9 proteinPMID:23954321
CASP9increases activityEXP 6480464CTDepigallocatechin gallate results in increased activity of CASP9 proteinPMID:15764647
CASP9increases cleavageEXP 6480464CTDepigallocatechin gallate analog results in increased cleavage of CASP9 proteinPMID:16115949
CASP9increases expressionEXP 6480464CTDepigallocatechin gallate results in increased expression of CASP9 proteinPMID:32512070
CASP9multiple interactionsEXP 6480464CTDepigallocatechin gallate inhibits the reaction [Nitroprusside binds to and results in increased activity of CASP9 protein]PMID:23665936
CASP9increases cleavageISOCasp9 (Mus musculus)6480464CTDepigallocatechin gallate results in increased cleavage of CASP9 proteinPMID:34600025
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