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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69005
Species: Mus musculus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3decreases activityISOSTAT3 (Homo sapiens)6480464CTDepigallocatechin gallate results in decreased activity of STAT3 proteinPMID:22348037
Stat3decreases expressionISOSTAT3 (Homo sapiens)6480464CTDepigallocatechin gallate results in decreased expression of STAT3 mRNA; epigallocatechin gallate results in decreased expression of STAT3 protein; epigallocatechin gallate results in decreased expression of STAT3 protein modified formPMID:20816778 PMID:22348037
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTD[docetaxel co-treated with epigallocatechin gallate co-treated with Quercetin] results in decreased expression of and results in decreased phosphorylation of STAT3 protein; [epigallocatechin gallate co-treated with Quercetin] promotes the reaction [docetaxel results in decreased phosphorylation of STAT3 protein]; [epigallocatechin gallate co-treated with Quercetin] results in decreased expression of and results in decreased phosphorylation of STAT3 protein; docetaxel promotes the reaction [[epigallocatechin gallate co-treated with Quercetin] results in decreased phosphorylation of STAT3 protein]PMID:25655047
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