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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ddit3increases expressionISODDIT3 (Homo sapiens)6480464CTDepigallocatechin gallate results in increased expression of DDIT3 mRNAPMID:16084531
Ddit3multiple interactionsISODDIT3 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 protein]; [epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 mRNA; [epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 protein; [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DDIT3 mRNA; [Sulindac co-treated with epigallocatechin gallate] results in increased expression of DDIT3 mRNA; U 0126 inhibits the reaction [[epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 mRNA]; U 0126 inhibits the reaction [[epigallocatechin gallate co-treated with Celecoxib] results in increased expression of DDIT3 protein]PMID:12628509 PMID:16463383 PMID:22079256
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