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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2multiple interactionsEXP 6480464CTDepigallocatechin gallate affects the reaction [Doxorubicin affects the expression of and affects the activity of SOD2 protein]PMID:20666448
Sod2affects activityISOSod2 (Mus musculus)6480464CTDepigallocatechin gallate affects the activity of SOD2 proteinPMID:25955525
Sod2decreases expressionISOSod2 (Mus musculus)6480464CTDepigallocatechin gallate results in decreased expression of SOD2 mRNAPMID:29175576
Sod2increases activityISOSOD2 (Homo sapiens)6480464CTDepigallocatechin gallate results in increased activity of SOD2 proteinPMID:26187476
Sod2increases expressionISOSod2 (Mus musculus)6480464CTDepigallocatechin gallate results in increased expression of SOD2 mRNA; epigallocatechin gallate results in increased expression of SOD2 proteinPMID:29175576 PMID:36056792
Sod2multiple interactionsISOSod2 (Mus musculus)6480464CTDepigallocatechin gallate inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD2 mRNA]PMID:36056792
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTD[epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] results in increased activity of SOD2 protein; [epigallocatechin gallate co-treated with leptomycin B] results in increased expression of SOD2 mRNA; SOD2 protein inhibits the reaction [epigallocatechin gallate analog results in increased abundance of Reactive Oxygen Species]PMID:16115949 PMID:25922640 PMID:26187476
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