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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3112
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc1
Name: ATP binding cassette subfamily C member 1
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc1decreases expressionISOABCC1 (Homo sapiens)6480464CTDepigallocatechin gallate results in decreased expression of ABCC1 proteinPMID:35218280
Abcc1multiple interactionsISOABCC1 (Homo sapiens)6480464CTD[Docetaxel co-treated with epigallocatechin gallate co-treated with Quercetin] results in decreased expression of ABCC1 protein; [Docetaxel co-treated with epigallocatechin gallate] results in decreased expression of ABCC1 protein; epigallocatechin gallate affects the reaction [Doxorubicin affects the expression of ABCC1 protein]PMID:25655047 PMID:35218280
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