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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2affects expressionEXP 6480464CTDepigallocatechin gallate affects the expression of BCL2 proteinPMID:22000973
Bcl2multiple interactionsEXP 6480464CTD[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; epigallocatechin gallate inhibits the reaction [Acrylamide results in decreased expression of BCL2 protein]PMID:28056603 PMID:33393703
Bcl2affects expressionISOBCL2 (Homo sapiens)6480464CTDepigallocatechin gallate affects the expression of BCL2 proteinPMID:15975156
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDepigallocatechin gallate results in decreased expression of BCL2 proteinPMID:34600025
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDepigallocatechin gallate analog results in decreased expression of BCL2 protein; epigallocatechin gallate results in decreased expression of BCL2 proteinPMID:15657356 PMID:16115949 PMID:20149610
Bcl2multiple interactionsISOBcl2 (Mus musculus)6480464CTDepigallocatechin gallate affects the reaction [mono-(2-ethylhexyl)phthalate affects the expression of BCL2 protein]; epigallocatechin gallate inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 mRNA]; epigallocatechin gallate inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]PMID:18656336 PMID:36056792 PMID:37286014
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[arsenic trioxide co-treated with epigallocatechin gallate] results in decreased expression of BCL2 protein; [decitabine co-treated with epigallocatechin gallate] affects the expression of BCL2 mRNA; CAT protein inhibits the reaction [epigallocatechin gallate analog results in decreased expression of BCL2 protein]; epigallocatechin gallate inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein]; epigallocatechin gallate inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]PMID:12672908 PMID:16115949 PMID:18250043 PMID:19557821 PMID:20950636
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