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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348437
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP9multiple interactionsEXP 6480464CTDepigallocatechin gallate affects the reaction [Doxorubicin affects the activity of MMP9 protein]; epigallocatechin gallate inhibits the reaction [Particulate Matter results in increased expression of MMP9 protein]PMID:31252129 PMID:35218280
MMP9decreases activityISOMmp9 (Mus musculus)6480464CTDepigallocatechin gallate results in decreased activity of MMP9 proteinPMID:11746506
MMP9multiple interactionsISOMmp9 (Mus musculus)6480464CTDepigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased activity of MMP9 protein]; epigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]PMID:16516891
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