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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735907
Species: Homo sapiens
RGD Object: Gene
Symbol: CHRNA2
Name: cholinergic receptor nicotinic alpha 2 subunit
Acc ID: CHEBI:4803
Term: epibatidine
Definition: An alkaloid that has formula C11H13ClN2.
Chemical ID: MESH:C082748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CHRNA2affects bindingISOChrna2 (Rattus norvegicus)2303194RGDEpibatidine binds to Chrna2 protein 
CHRNA2affects bindingISOChrna2 (Rattus norvegicus)2303195RGDepibatidine binds to Chrnb4 protein in the retina 
CHRNA2affects bindingEXP 6480464CTD[CHRNB4 protein binds to CHRNA2 protein] which binds to epibatidinePMID:9454827
CHRNA2multiple interactionsISOChrna2 (Rattus norvegicus)6480464CTDepibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNB2 protein]; sazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNB2 protein]]PMID:21905669
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