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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrnb4
Name: cholinergic receptor nicotinic beta 4 subunit
Acc ID: CHEBI:4803
Term: epibatidine
Definition: An alkaloid that has formula C11H13ClN2.
Chemical ID: MESH:C082748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrnb4affects bindingEXP 2303195RGDepibatidine binds to Chrnb4 protein in the retina 
Chrnb4affects bindingEXP 6480464CTD[CHRNA3 protein binds to CHRNB4 protein] which binds to epibatidine; epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]PMID:15615518 PMID:9687574
Chrnb4multiple interactionsEXP 6480464CTDepibatidine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; epibatidine binds to [NACHRALPHA1 protein co-treated with CHRNB4 protein]; epibatidine binds to [NACHRALPHA2 protein co-treated with CHRNB4 protein]; epibatidine binds to [NACHRALPHA3 protein co-treated with CHRNB4 protein]PMID:10728888 PMID:15615518
Chrnb4affects bindingISOCHRNB4 (Homo sapiens)6480464CTD[CHRNB4 protein binds to CHRNA2 protein] which binds to epibatidine; [CHRNB4 protein binds to CHRNA3 protein] which binds to epibatidine; [CHRNB4 protein binds to CHRNA4 protein] which binds to epibatidinePMID:9454827
Chrnb4multiple interactionsISOCHRNB4 (Homo sapiens)6480464CTD2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane inhibits the reaction [epibatidine binds to [CHRNA3 protein binds to CHRNB4 protein]]; epibatidine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]PMID:21942635 PMID:22060139
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