Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	731479
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Slc2a4
Name:	solute carrier family 2 (facilitated glucose transporter), member 4

Acc ID:	CHEBI:47977
Term:	2-amino-2-deoxy-D-glucopyranose
Definition:	A D-glucosamine whose structure comprises D-glucopyranose having an amino substituent at position 2.
Chemical ID:	MESH:D005944

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Slc2a4	increases uptake	EXP		6480464	CTD	SLC2A4 protein results in increased uptake of Glucosamine	PMID:19373748
Slc2a4	multiple interactions	EXP		6480464	CTD	Glucosamine inhibits the reaction [SLC2A4 protein results in increased uptake of Glucose]; Glucose inhibits the reaction [SLC2A4 protein results in increased uptake of Glucosamine]	PMID:19373748
Slc2a4	decreases expression	ISO	Slc2a4 (Rattus norvegicus)	6480464	CTD	Glucosamine results in decreased expression of SLC2A4 mRNA; Glucosamine results in decreased expression of SLC2A4 protein	PMID:20165829
Slc2a4	decreases expression	ISO	SLC2A4 (Homo sapiens)	6480464	CTD	Glucosamine results in decreased expression of SLC2A4 mRNA; Glucosamine results in decreased expression of SLC2A4 protein	PMID:20165829
Slc2a4	multiple interactions	ISO	Slc2a4 (Rattus norvegicus)	6480464	CTD	4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein]; ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA]; ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein]; ursodoxicoltaurine inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA]; ursodoxicoltaurine inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein]	PMID:20165829
Slc2a4	multiple interactions	ISO	SLC2A4 (Homo sapiens)	6480464	CTD	4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein]; ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA]; ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein]; ursodoxicoltaurine inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA]; ursodoxicoltaurine inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein]	PMID:20165829

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