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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3865
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Timp3
Name: TIMP metallopeptidase inhibitor 3
Acc ID: CHEBI:47977
Term: 2-amino-2-deoxy-D-glucopyranose
Definition: A D-glucosamine whose structure comprises D-glucopyranose having an amino substituent at position 2.
Chemical ID: MESH:D005944
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp3increases expressionEXP 6480464CTDGlucosamine results in increased expression of TIMP3 mRNAPMID:17109745
Timp3multiple interactionsEXP 6480464CTDGlucosamine inhibits the reaction [IL1B results in decreased expression of TIMP3 mRNA]; IL1B affects the reaction [Glucosamine results in increased expression of TIMP3 mRNA]PMID:17109745
Timp3multiple interactionsISOTIMP3 (Homo sapiens)6480464CTD[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in increased expression of TIMP3 mRNAPMID:17605605
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