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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347893
Species: Homo sapiens
RGD Object: Gene
Symbol: HSD3B1
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Acc ID: CHEBI:4791
Term: endosulfan
Definition: A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.
Chemical ID: MESH:D004726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSD3B1multiple interactionsEXP 6480464CTD[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HSD3B1 mRNAPMID:26159488
HSD3B1affects expressionISOHsd3b1 (Rattus norvegicus)6480464CTDEndosulfan affects the expression of HSD3B1 mRNAPMID:29391264
HSD3B1decreases activityISOHsd3b1 (Rattus norvegicus)6480464CTDEndosulfan results in decreased activity of HSD3B1 proteinPMID:11225895
HSD3B1increases expressionISOHsd3b1 (Mus musculus)6480464CTDEndosulfan results in increased expression of HSD3B1 mRNAPMID:30502743
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