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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1312684
Species: Mus musculus
RGD Object: Gene
Symbol: Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Acc ID: CHEBI:4791
Term: endosulfan
Definition: A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.
Chemical ID: MESH:D004726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ezh2decreases expressionISOEzh2 (Rattus norvegicus)6480464CTDEndosulfan results in decreased expression of EZH2 mRNAPMID:29391264
Ezh2increases expressionISOEZH2 (Homo sapiens)6480464CTDEndosulfan results in increased expression of EZH2 mRNAPMID:29054638
Ezh2multiple interactionsISOEZH2 (Homo sapiens)6480464CTDEndosulfan results in increased expression of and results in increased activity of EZH2 proteinPMID:29054638
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