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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10451
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:4791
Term: endosulfan
Definition: A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.
Chemical ID: MESH:D004726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1increases expressionEXP 6480464CTDEndosulfan analog results in increased expression of CYP2E1 mRNA; Endosulfan results in increased expression of CYP2E1 mRNAPMID:29702342
Cyp2e1decreases expressionISOCYP2E1 (Homo sapiens)6480464CTDEndosulfan results in decreased expression of CYP2E1 mRNA; Endosulfan results in decreased expression of CYP2E1 proteinPMID:26159488 PMID:28673560
Cyp2e1increases expressionISOCyp2e1 (Rattus norvegicus)6480464CTDEndosulfan results in increased expression of CYP2E1 mRNAPMID:29391264
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTD[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP2E1 mRNA; Endosulfan promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP2E1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Endosulfan results in decreased expression of CYP2E1 mRNA]PMID:26159488 PMID:28673560
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