Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10187
Species: Mus musculus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:4791
Term: endosulfan
Definition: A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.
Chemical ID: MESH:D004726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ardecreases expressionEXP 6480464CTDEndosulfan results in decreased expression of AR mRNAPMID:25077688
Armultiple interactionsEXP 6480464CTDTestosterone Propionate inhibits the reaction [Endosulfan results in decreased expression of AR mRNA]PMID:25077688
Araffects bindingISOAr (Rattus norvegicus)6480464CTDEndosulfan binds to AR proteinPMID:14565775
Ardecreases expressionISOAr (Rattus norvegicus)6480464CTDEndosulfan results in decreased expression of AR proteinPMID:28935589
Ardecreases expressionISOAR (Homo sapiens)6480464CTDEndosulfan results in decreased expression of AR mRNAPMID:33728745
Armultiple interactionsISOAR (Homo sapiens)6480464CTDDihydrotestosterone inhibits the reaction [Endosulfan results in increased activity of AR protein]; Endosulfan inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Endosulfan inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Endosulfan inhibits the reaction [Metribolone results in increased activity of AR protein]PMID:15064155 PMID:18324785 PMID:21310686 PMID:33049310
Go Back to source page   Continue to Ontology report