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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11429
Species: Mus musculus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:47898
Term: 4'-epidoxorubicin
Definition: An anthracycline that is the 4'-epi-isomer of doxorubicin.
Chemical ID: MESH:D015251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionEXP 6480464CTDEpirubicin results in increased expression of TNF mRNA; Epirubicin results in increased expression of TNF proteinPMID:26646421 PMID:29505745
Tnfmultiple interactionsEXP 6480464CTDpaeonol inhibits the reaction [Epirubicin results in increased expression of TNF mRNA]; paeonol inhibits the reaction [Epirubicin results in increased expression of TNF protein]PMID:26646421 PMID:29505745
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