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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735618
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS3
Name: nitric oxide synthase 3
Acc ID: CHEBI:4784
Term: enalapril
Definition: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).
Chemical ID: MESH:D004656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS3affects expressionISONos3 (Rattus norvegicus)6480464CTDEnalapril affects the expression of NOS3 mRNAPMID:12176110 PMID:20571278
NOS3increases expressionISONos3 (Mus musculus)6480464CTDEnalapril results in increased expression of NOS3 proteinPMID:20720404 PMID:25037058
NOS3multiple interactionsISONos3 (Mus musculus)6480464CTD[paricalcitol co-treated with Enalapril] results in increased expression of NOS3 protein; Enalapril inhibits the reaction [Dexamethasone results in decreased expression of NOS3 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in decreased expression of NOS3 protein]]PMID:20720404 PMID:30940551
NOS3multiple interactionsISONos3 (Rattus norvegicus)6480464CTD[Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNA; Enalapril inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein]PMID:16197366 PMID:20571278
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