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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10802
Species: Mus musculus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:4784
Term: enalapril
Definition: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).
Chemical ID: MESH:D004656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6multiple interactionsEXP 6480464CTDEnalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL6 protein]PMID:19114890
Il6affects response to substanceISOIL6 (Homo sapiens)6480464CTDIL6 gene polymorphism affects the susceptibility to EnalaprilPMID:15342284
Il6multiple interactionsISOIl6 (Rattus norvegicus)6480464CTDEnalapril inhibits the reaction [Acrolein results in increased expression of IL6 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]PMID:17167242 PMID:19114890 PMID:21265103 PMID:30623541
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