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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730878
Species: Homo sapiens
RGD Object: Gene
Symbol: NPPA
Name: natriuretic peptide A
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NPPAincreases expressionISONppa (Mus musculus)6480464CTDsulforaphane results in increased expression of NPPA mRNAPMID:30529165
NPPAmultiple interactionsISONppa (Mus musculus)6480464CTDNFE2L2 gene mutant form inhibits the reaction [sulforaphane inhibits the reaction [AGT protein modified form results in increased expression of NPPA protein]]; sulforaphane inhibits the reaction [AGT protein modified form results in increased expression of NPPA mRNA]; sulforaphane inhibits the reaction [AGT protein modified form results in increased expression of NPPA protein]PMID:29353218
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