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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1557448
Species: Mus musculus
RGD Object: Gene
Symbol: Top2b
Name: topoisomerase (DNA) II beta
Acc ID: CHEBI:4776
Term: ellipticine
Definition: A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.
Chemical ID: MESH:C034192
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2bdecreases response to substanceISORGD:13506376480464CTDTOP2B protein mutant form results in decreased susceptibility to ellipticine

PMID:16239602
Top2bincreases response to substanceISORGD:13506376480464CTDTOP2B protein mutant form results in increased susceptibility to ellipticine

PMID:15322234
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.