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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:47657
Term: roflumilast
Definition: A benzamide obtained by formal condensation of the carboxy group of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid with the amino group of 3,5-dichloropyridin-4-amine. Used for treatment of bronchial asthma and chronic obstructive pulmonary disease.
Chemical ID: MESH:C424423
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2multiple interactionsEXP 6480464CTD[Roflumilast co-treated with Rotenone] results in increased expression of and results in increased localization of NFE2L2 protein; Roflumilast promotes the reaction [Cisplatin results in increased expression of NFE2L2 mRNA]PMID:33757793 PMID:37105514
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDRoflumilast results in increased expression of NFE2L2 mRNAPMID:33757793
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDCisplatin promotes the reaction [Roflumilast results in increased expression of NFE2L2 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased expression of NFE2L2 mRNA]PMID:33757793
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