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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735259
Species: Homo sapiens
RGD Object: Gene
Symbol: ACADM
Name: acyl-CoA dehydrogenase medium chain
Acc ID: CHEBI:47612
Term: bezafibrate
Definition: A monocarboxylic acid amide obtained by the formal condensation of the carboxy group of 4-chlorobenzoic acid with the amino group of 2-[4-(2-aminoethyl)phenoxy]-2-methylpropanoic acid. Benafibrate is used for the treatment of hyperlipidaemia.
Chemical ID: MESH:D001629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACADMincreases expressionISOAcadm (Mus musculus)6480464CTDBezafibrate results in increased expression of ACADM mRNAPMID:19124612
ACADMmultiple interactionsISOAcadm (Mus musculus)6480464CTDBezafibrate inhibits the reaction [CYP19A1 gene mutant form results in decreased expression of ACADM mRNA]; Bezafibrate inhibits the reaction [SLC27A2 gene mutant form results in decreased expression of ACADM mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACADM mRNA]PMID:11929713 PMID:19124612
ACADMmultiple interactionsISOAcadm (Rattus norvegicus)6480464CTDBezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of ACADM mRNA]PMID:26190035
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