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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731542
Species: Homo sapiens
RGD Object: Gene
Symbol: NOX4
Name: NADPH oxidase 4
Acc ID: CHEBI:47612
Term: bezafibrate
Definition: A monocarboxylic acid amide obtained by the formal condensation of the carboxy group of 4-chlorobenzoic acid with the amino group of 2-[4-(2-aminoethyl)phenoxy]-2-methylpropanoic acid. Benafibrate is used for the treatment of hyperlipidaemia.
Chemical ID: MESH:D001629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOX4increases expressionISONox4 (Mus musculus)6480464CTDBezafibrate results in increased expression of NOX4 proteinPMID:20594415
NOX4multiple interactionsISONox4 (Rattus norvegicus)6480464CTDBezafibrate inhibits the reaction [Streptozocin results in increased expression of NOX4 mRNA]PMID:16979161
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