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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:47612
Term: bezafibrate
Definition: A monocarboxylic acid amide obtained by the formal condensation of the carboxy group of 4-chlorobenzoic acid with the amino group of 2-[4-(2-aminoethyl)phenoxy]-2-methylpropanoic acid. Benafibrate is used for the treatment of hyperlipidaemia.
Chemical ID: MESH:D001629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDBezafibrate inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]

PMID:26190035
decreases expressionISORGD:694746480464CTDBezafibrate results in decreased expression of SREBF1 mRNA, Bezafibrate results in decreased expression of SREBF1 protein

PMID:19124612
increases expressionISORGD:694746480464CTDBezafibrate results in increased expression of SREBF1 mRNA, Bezafibrate results in increased expression of SREBF1 protein

PMID:19124612
multiple interactionsISORGD:694736480464CTDSREBF1 protein inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]

PMID:11779144
multiple interactionsISORGD:694746480464CTD[Bezafibrate results in decreased expression of SREBF1] which results in decreased abundance of Triglycerides, PPARA protein affects the susceptibility to [Bezafibrate results in decreased expression of SREBF1 mRNA], PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SREBF1 protein]

PMID:19124612
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.