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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307794
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bag3
Name: BAG cochaperone 3
Acc ID: CHEBI:47575
Term: ABT-737
Definition: A biphenyl that is 4-chloro-1,1'-biphenyl substituted by a (4-{4-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene-1-sulfonyl)carbamoyl]phenyl}piperazin-1-yl)methyl group at position 2'. It is a BH3-mimetic drug which targets the anti-apoptotic B-cell lymphoma-2 (BCL-2) family proteins, including BCL-2, BCL-xL, and BCL-w, and induces apoptosis in cancer cells.
Chemical ID: MESH:C501332
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bag3decreases response to substanceISORGD:13171926480464CTDBAG3 protein results in decreased susceptibility to ABT-737

PMID:23341456
Bag3multiple interactionsISORGD:13171926480464CTD[BAG3 protein results in increased stability of MCL1 protein] which results in decreased susceptibility to ABT-737 BAG3 mutant form inhibits the reaction [MCL1 protein results in decreased susceptibility to ABT-737]

PMID:23341456
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