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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732102
Species: Mus musculus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2affects activityISOKCNH2 (Homo sapiens)6480464CTDKetoconazole affects the activity of KCNH2 protein mutant formPMID:17965736
Kcnh2affects localizationISOKCNH2 (Homo sapiens)6480464CTDKetoconazole affects the localization of KCNH2; Ketoconazole affects the localization of KCNH2 protein mutant formPMID:17965736
Kcnh2decreases activityISOKCNH2 (Homo sapiens)6480464CTDKetoconazole results in decreased activity of KCNH2; Ketoconazole results in decreased activity of KCNH2 proteinPMID:16542653 PMID:17965736 PMID:24052561 PMID:29143966 PMID:9694927
Kcnh2decreases response to substanceISOKCNH2 (Homo sapiens)6480464CTDKCNH2 protein mutant form results in decreased susceptibility to KetoconazolePMID:16542653
Kcnh2multiple interactionsISOKCNH2 (Homo sapiens)6480464CTD[Ketoconazole co-treated with desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with Loratadine] results in decreased activity of KCNH2 protein; Ketoconazole binds to and results in decreased activity of KCNH2 protein; Terfenadine promotes the reaction [Ketoconazole results in decreased activity of KCNH2 protein]PMID:15272206 PMID:29143966 PMID:9694927
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