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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346266
Species: Homo sapiens
RGD Object: Gene
Symbol: FAS
Name: Fas cell surface death receptor
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FASmultiple interactionsEXP 6480464CTDKetoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]]PMID:15703382
FASincreases expressionISOFas (Mus musculus)6480464CTDKetoconazole results in increased expression of FAS mRNAPMID:25808816
FASincreases expressionISOFas (Rattus norvegicus)6480464CTDKetoconazole results in increased expression of FAS mRNAPMID:25808816
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