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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1624096
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2c38
Name: cytochrome P450, family 2, subfamily c, polypeptide 38
Acc ID: CHEBI:47499
Term: imipramine
Definition: A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Chemical ID: MESH:D007099
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c38affects metabolic processingISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 protein affects the metabolism of ImipraminePMID:15286053
Cyp2c38multiple interactionsISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 protein results in decreased methylation of and results in increased activity of Imipramine; Organophosphorus Compounds inhibits the reaction [CYP2C19 protein results in decreased methylation of and results in increased activity of Imipramine]PMID:15922009
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