Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	12079702
Species:	Canis lupus familiaris
RGD Object:	Gene
Symbol:	IL6
Name:	interleukin 6

Acc ID:	CHEBI:47495
Term:	N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide
Definition:	A member of the class of isoquinolines that is the sulfonamide obtained by formal condensation of the sulfo group of isoquinoline-5-sulfonic acid with the primary amino group of N(1)-[3-(4-bromophenyl)prop-2-en-1-yl]ethane-1,2-diamine. It is a protein kinase A inhibitor.
Chemical ID:	MESH:C063509

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
IL6	decreases expression	EXP		6480464	CTD	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of IL6 protein	PMID:24105867
IL6	multiple interactions	EXP		6480464	CTD	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]	PMID:24105867

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