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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730855
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD1
Name: superoxide dismutase 1
Acc ID: CHEBI:47381
Term: diclofenac
Definition: A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Chemical ID: MESH:D004008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD1increases expressionEXP 6480464CTDDiclofenac results in increased expression of SOD1 mRNAPMID:29027214
SOD1decreases activityISOSod1 (Rattus norvegicus)6480464CTDDiclofenac results in decreased activity of SOD1 proteinPMID:28535741
SOD1increases expressionISOSod1 (Rattus norvegicus)6480464CTDDiclofenac results in increased expression of SOD1 mRNAPMID:29027214
SOD1increases secretionISOSod1 (Mus musculus)6480464CTDDiclofenac results in increased secretion of SOD1 proteinPMID:24038040
SOD1increases secretionISOSod1 (Rattus norvegicus)6480464CTDDiclofenac results in increased secretion of SOD1 proteinPMID:24038040
SOD1multiple interactionsISOSod1 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Diclofenac results in decreased activity of SOD1 protein]; Silymarin inhibits the reaction [Diclofenac results in decreased activity of SOD1 protein]PMID:28535741
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