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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344832
Species: Homo sapiens
RGD Object: Gene
Symbol: TNFSF10
Name: TNF superfamily member 10
Acc ID: CHEBI:47344
Term: alvocidib
Definition: A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.
Chemical ID: MESH:C077990
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFSF10increases expressionEXP 6480464CTDalvocidib results in increased expression of TNFSF10PMID:16820931
TNFSF10increases response to substanceEXP 6480464CTDalvocidib results in increased susceptibility to TNFSF10PMID:16951203
TNFSF10multiple interactionsEXP 6480464CTD[alvocidib co-treated with TNFSF10 protein] results in decreased expression of BID protein; [alvocidib co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [alvocidib co-treated with TNFSF10 protein] results in increased localization of BAX proteinPMID:16951203
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