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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621628
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a12
Name: solute carrier family 22 member 12
Acc ID: CHEBI:4732
Term: E3040
Definition: A member of the class of benzothiazoles that is 1,3-benzothiazole substituted by a methylnitrilo group, (pyridin-3-yl)methyl group, methyl group, hydroxy group and methyl group at position 2,4,5,6 and 7, respectively. It is a dual inhibitor of 5-lipoxygenase and thromboxane A2 synthetase and exhibits anti-inflammatory properties. The drug was being developed by Eisai (Tokyo, Japan) for the treatment of bowel disease.
Chemical ID: MESH:C095803
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a12multiple interactionsISOSLC22A12 (Homo sapiens)6480464CTDE 3040 inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]PMID:21272127
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