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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:47318
Term: 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime
Definition: An imidazothiazole that has formula C19H12Cl3N3OS.
Chemical ID: MESH:C475093
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:694736480464CTD6-(4-chlorophenyl)imidazo(2, 1-b)(1, 3)thiazole-5-carbaldehyde O-(3, 4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA

PMID:21768169
increases expressionISORGD:694736480464CTD6-(4-chlorophenyl)imidazo(2, 1-b)(1, 3)thiazole-5-carbaldehyde O-(3, 4-dichlorobenzyl)oxime results in increased expression of SREBF1 mRNA

PMID:27180240
multiple interactionsISORGD:694736480464CTD[6-(4-chlorophenyl)imidazo(2, 1-b)(1, 3)thiazole-5-carbaldehyde O-(3, 4-dichlorobenzyl)oxime co-treated with Oleic Acid] results in decreased expression of SREBF1 mRNA, [Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2, 1-b)(1, 3)thiazole-5-carbaldehyde O-(3, 4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA], Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2, 1-b)(1, 3)thiazole-5-carbaldehyde O-(3, 4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA], NR1I3 mutant form inhibits the reaction [6-(4-chlorophenyl)imidazo(2, 1-b)(1, 3)thiazole-5-carbaldehyde O-(3, 4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA], NR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2, 1-b)(1, 3)thiazole-5-carbaldehyde O-(3, 4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]], NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2, 1-b)(1, 3)thiazole-5-carbaldehyde O-(3, 4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]], Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2, 1-b)(1, 3)thiazole-5-carbaldehyde O-(3, 4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]

PMID:21768169, PMID:30611723
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.